Neural Implications of Post-COVID-19 Condition: Preliminary Insights
| Autoři | |
|---|---|
| Rok publikování | 2023 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Background: Post-SARS-CoV-2 infection, many patients exhibit persistent symptoms termed the post- COVID-19 condition, encompassing fatigue, cognitive dysfunction, and neuropsychiatric issues. The potential link between this condition and increased risk of psychiatric or neurodegenerative disorders post-infection has raised concerns. Neuroimaging is viewed as a key tool for understanding this condition's biological foundation. Aim and Objectives: The study aimed to explore COVID-19's impact on neural plasticity and brain function. Objectives included identifying neuroanatomical signatures using MR imaging, EEG, and cognitive parameters; charting the condition's progression; and assessing acute COVID-19 or its treatment's influence on the condition's manifestation. Methods: A longitudinal study was conducted on post SARS-CoV-2 patients, categorized based on post-COVID-19 symptoms. Evaluations occurred at baseline, 12, and 24 months, involving MRI, EEG, and blood tests. Preliminary Results: Based on the initial timepoint, several patterns were observed among the 67 post-COVID-19 and 52 recovery subjects. An elevation in T2 and T2rho relaxation times was noted in post- COVID-19 subjects within the prefrontal and mesiotemporal areas, suggesting potential iron involvement. A reduction in T1rho relaxation times in these regions was also observed. These neural patterns bear similarities to processes typically seen during aging. However, results from subcortical regions, particularly the hippocampus and cerebellum, were inconsistent. Limitations: The findings are preliminary and require a broader analysis, including rsfMRI and DWI, for comprehensive understanding. Conclusion: Early findings suggest neural ramifications of the post-COVID-19 condition, drawing parallels with aging. Further research is anticipated for a deeper understanding. |
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