Cow's Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6-12 months: a cross-sectional study

Autoři	JANKIEWICZ Mateusz AHMED Fatme BAJEROVÁ Kateřina ROCA Maria Eva Carvajal DUPONT Christophe HUYSENTRUYT Koen KUITUNEN Mikael MEYER Rosan PANCHEVA Rouzha KONINCKX Carmen Ribes SALVATORE Silvia SHAMIR Raanan STAIANO Annamaria VANDENPLAS Yvan SZAJEWSKA Hania
Rok publikování	2024
Druh	Článek v odborném periodiku
Časopis / Zdroj	European journal of pediatrics
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://link.springer.com/article/10.1007/s00431-023-05334-0
Doi	http://dx.doi.org/10.1007/s00431-023-05334-0
Klíčová slova	Cow's milk allergy; Awareness; Tool; Infant feeding; CoMiSS
Popis	The Cow's Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating cow's milk-related symptoms. Previous studies have focused on providing CoMiSS values for healthy and symptomatic infants aged 0-6 months. However, there is a notable gap in the literature concerning CoMiSS values for infants older than 6 months. This cross-sectional study aimed to determine CoMiSS values in presumed healthy infants who have completed 6 months and are up to 12 months old, hereafter referred to as 6 to 12 months old. Physicians from six European countries prospectively determined CoMiSS values in infants attending well-child clinics. Exclusion criteria included preterm delivery, acute or chronic disease, and the consumption of a therapeutic formula, dietary supplements (except vitamins), or medication. The following information was collected: gestational age, gender, age, type of feed (breast milk or infant formula), and complementary feeding. Descriptive statistics were summarized with mean and standard deviation for normally distributed continuous variables, median and IQR for non-normally distributed variables, and differences in CoMiSS values were analyzed with appropriate tests. Data from 609 infants were obtained. The overall median (Q1-Q3) CoMiSS values were 3 (1-5). Significant differences were found across age groups (p < 0.001), but not across groups based on gender (p = 0.551) or feeding type (p = 0.880).Conclusions: This study provided CoMiSS values in presumed healthy infants aged 6-12 months. Additional studies should be conducted to establish the use of CoMiSS to assess cow's milk-related symptoms in infants 6 months and older.