Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry

Autoři	BRIOLI Annamaria LOMAIA Elza FABISCH Christian SACHA Tomasz KLAMOVA Hana MOROZOVA Elena GOLOS Aleksandra ERNST Philipp OLSSON-STROMBERG Ulla ŽÁČKOVÁ Daniela NICOLINI Franck E BAO Han CASTAGNETTI Fausto PATKOWSKA Elzbieta MAYER Jiří HIRSCHBUEHL Klaus PODGORNIK Helena PACZKOWSKA Edyta PARRY Anne ERNST Thomas VOSKANYAN Astghik SZCZEPANEK Elzbieta SAUSSELE Susanne FRANKE Georg-Nikolaus KIANI Alexander FABER Edgar KRAUSE Stefan CASADO Luis Felipe LEWANDOWSKI Krzysztof EDER Matthias ANHUT Peter GIL Justyna SUEDHOFF Thomas HEBART Holger HEIBL Sonja PFIRRMANN Markus HOCHHAUS Andreas LAUSEKER Michael
Rok publikování	2024
Druh	Článek v odborném periodiku
Časopis / Zdroj	Leukemia
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.nature.com/articles/s41375-024-02204-y
Doi	http://dx.doi.org/10.1038/s41375-024-02204-y
Klíčová slova	chronic myeloid leukemia; tyrosine kinase inhibitor era
Popis	Blast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected heterogeneity of the entity, lacking a clear treatment standard. Outcomes remain dismal, with a median overall survival of 23.8 months (median follow up 27.8 months). Allogeneic stem cell transplantation (alloSCT) increases the rate of deep molecular responses. De novo BP and BP evolving from a previous CML do show slightly different features, suggesting a different biology between the two entities. Data show that outside clinical trials and in a real-world setting treatment of blast phase is individualized according to disease- and patient-related characteristics, with the aim of blast clearance prior to allogeneic stem cell transplantation. AlloSCT should be offered to all patients eligible for this procedure.