Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats
| Autoři | |
|---|---|
| Rok publikování | 1999 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | The Journal of Pharmacology and Exper. Therapeutics |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://jpet.aspetjournals.org/content/291/1/239.long |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | Rats; methamphetamine; serotonin agonists; serotonin antagonists; serotonin uptake inhibitors; discriminative behaviour |
| Popis | The present data suggest that the 5-HT system plays a modulatory role in the discriminative stimulus effects of methamphetamine. These effects appear to be mediated through 5-HT release and blockade of reuptake and subsequent activation of 5-HT(2A/2C) receptors, with limited involvement of other 5-HT receptor subtypes. |
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