Generation of humanized bone marrow-like niche for leukemic xenotransplantation in mice: comparison of biomaterials

• Autoři: HERUDKOVÁ Zdeňka; SOKOL Filip; VLAŽNÝ Jakub; LIŠKOVÁ Květoslava; KŘEN Leoš; REPKO Martin; VOJTOVÁ Lucy; ŠUSTKOVÁ Zuzana; RÁČIL Zdeněk; MAYER Jiří; ČULEN Martin
• Rok publikování: 2020
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: Engraftment of leukemic cells in immunodeficient mice can be improved by incorporation of a humanized bone marrow microenvironment, formed by mesenchymal stromal cells (MSC) and a suitable biomaterial. Various biomaterials ranging from ceramic calcium phosphate to extracellular matrix (ECM) gels were reported so far but their comparison is lacking.

Související projekty

• CEITEC 2020