Expression of toll-like and formyl peptide receptors in choroid plexus after subarachnoid hemorrhage
| Autoři | |
|---|---|
| Rok publikování | 2019 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | A subarachnoid hemorrhage is a life threatening state, which can be caused by aneurysm rupture, arteriovenous malformation or trauma. In our previous experiments, we found cellular immune reaction in choroid plexus after SAH. Therefore, the main aim of presented study was to investigate receptor mediated reaction to SAH. We focused on the expression of toll-like receptors (TLR) 4, 9 and formyl-peptide receptor (FPR) 2 after SAH. Material and Methods: The experiments were performed on 16 Wistar rats (males, 250g). SAH was induced by injection of blood into the cisterna magna, while control group received artificial CSF. The animals were left to survive for 1, 3 and 7 days from the application. After time of survival, the SAH and control together with naive rats were perfused transcardially with Zamboni´s fixative. Coronal cryostat sections through the brains were cut and immunostained for TLR4, TLR9 and FPR2. |
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