Asymmetric One-Pot Conjugate Addition of Grignard Reagents to alpha,beta-Unsaturated Compounds Followed by Reaction with Carbenium Ions

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	DRUSAN Michal RAKOVSKÝ Erik MAREK Jaromír ŠEBESTA Radovan
Rok publikování	2015
Druh	Článek v odborném periodiku
Časopis / Zdroj	ADVANCED SYNTHESIS & CATALYSIS
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
www	http://onlinelibrary.wiley.com/doi/10.1002/adsc.201500074/abstract;jsessionid=6039F4AD8F14C5AFBD11F8B684CAF703.f03t04
Doi	http://dx.doi.org/10.1002/adsc.201500074
Obor	Organická chemie
Klíčová slova	asymmetric catalysis; carbocations; conjugate addition; domino reactions; ferrocene ligands
Popis	Asymmetric catalytic multistep reactions enable the formation of structurally complex compounds from simple starting materials. Enantioselective Cu-catalyzed 1,4-additions of Grignard reagents to Michael acceptors form reactive chiral enolates. We show here that these chiral enolates react in a one-pot fashion with naked carbenium ions, such as tropylium, 1,3-benzodithiolium, and dianisylmethylium ions. The corresponding products were obtained in good yields, with enantioselectivities up to 96% ee and high diastereomeric purities.
Související projekty:	CEITEC - open access