Cell-Free DNA for Minimal Residual Disease Monitoring in Multiple Myeloma Patients

• Autoři: BEŠŠE Lenka; DRANDI Daniela; SEDLAŘÍKOVÁ Lenka; OLIVA Stefania; GAMBELLA Manuela; OMEDE Paola; ADAM Zdeněk; POUR Luděk; ŠEVČÍKOVÁ Sabina; BOCCADORO Mario; PALUMBO Antonio; HÁJEK Roman
• Rok publikování: 2014
• Druh: Další prezentace na konferencích
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: Circulating nucleic acids, such as cell-free DNA (cf-DNA), are becoming a promising minimally-invasive diagnostic tool for cancer detection. Recent studies demonstrated that tumor-derived cf-DNA can be used to monitor tumor burden and response to treatment in patients (pts) with solid tumors as well as hematological malignancies (Dawson et al, 2013, Armand et al, 2013). In this study we investigated the clinical utility of cf-DNA in the monitoring of minimal residual disease (MRD) of pts with multiple myeloma (MM) carrying the tumor specific immunoglobulin (IGH) rearrangement.