Pancreatic stone protein – A possible biomarker of multiorgan failure and mortality in children sepsis
| Autoři | |
|---|---|
| Rok publikování | 2014 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Cytokine |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1016/j.cyto.2014.01.009 |
| Obor | Pediatrie |
| Klíčová slova | Children; Mortality; Pancreatic stone protein; Regenerating protein 1 alpha; Sepsis |
| Popis | Pancreatic stone protein is associated with infection. Pancreatic stone protein did not differ between SIRS and sepsis. Pancreatic stone protein levels were higher in patients who died. Pancreatic stone protein (PSP)/regenerating protein 1-alpha (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/. reg among critically ill pediatric patients is unknown. The aim of this pilot study was to evaluate PSP/. reg in children with systemic inflammatory response syndrome or sepsis.Prospective observational study, a five day evaluation period in children 0-19. years old with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of PSP/. reg were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis.PSP/. reg levels did not differ between patients with systemic inflammatory response syndrome and septic condition until organ dysfunction signs were present. PSP/. reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with MODS. Patients who died tended to have higher PSP/. reg levels. |