Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins - A Review

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	ŠKUTKOVÁ Helena BABULA Petr STIBOROVA Marie ECKSCHLAGER Tomáš TRNKOVÁ Libuše PROVAZNIK Ivo HUBÁLEK Jaromír KIZEK René ADAM Vojtech
Rok publikování	2012
Druh	Článek v odborném periodiku
Časopis / Zdroj	International Journal of Electrochemical Science
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Obor	Fyzikální chemie a teoretická chemie
Klíčová slova	Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H
Popis	Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.