Molecular Dynamics Simulations of RNA Molecules

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	ŠPONER Jiří OTYEPKA Michal BANÁŠ Pavel RÉBLOVÁ Kamila WALTER Nils
Rok publikování	2012
Druh	Kapitola v knize
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
Popis	The central role of RNA in numerous biological processes including translation, protein localization, gene regulation, RNA processing, and viral replication calls for a detailed understanding of RNA function, structure, and conformational dynamics. Accompanying and enhancing our increasing appreciation of RNA is the rapidly expanding availability of high-resolution structures of RNAs and RNA-protein (RNP) complexes. These atomic resolution snapshots provide detailed rationalization for existing biochemical data. However, biological function depends on the dynamic evolution of structures along functional pathways. A complete understanding of the relevant structural dynamics exhibited by RNA requires monitoring timescales from picoseconds to hours through the application of a correspondingly broad range of techniques, with careful consideration given to the scope and limitation of each approach.
Související projekty:	Biomolekulární centrum