Self-reported history of infections and the risk of non-Hodgkin lymphoma: An InterLymph pooled analysis

Autoři	BECKER Nikolaus FALSTER Michael O. VAJDIC Claire M DE SANJOSE Silvia MARTINEZ-MAZA Otoniel BRACCI Paige M MELBYE Mads SMEDBY Karin Ekstrom ENGELS Eric A TURNER Jennifer VINEIS Paolo COSTANTINI Adele Seniori HOLLY Elizabeth A SPINELLI John J LA VECCHIA Carlo ZHENG Tongzhang CHIU Brian C H MONTELLA Maurizio COCCO Pierluigi MAYNADIE Marc FORETOVÁ Lenka STAINES Anthony BRENNAN Paul DAVIS Scott SEVERSON Richard CERHAN James R BREEN Elizabeth C BIRMANN Brenda COZEN Wendy GRULICH Andrew E NEWTON Robert
Rok publikování	2012
Druh	Článek v odborném periodiku
Časopis / Zdroj	International journal of cancer
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1002/ijc.27438
Obor	Onkologie a hematologie
Klíčová slova	Non-Hodgkin lymphoma; Infection; pooled analysis
Popis	We performed a pooled analysis of data on self-reported history of infections in relation to the risk of non-Hodgkin lymphoma (NHL) from 17 casecontrol studies that included 12,585 cases and 15,416 controls aged 1696 years at recruitment. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were estimated in two-stage random-effect or joint fixed-effect models, adjusting for age, sex and study centre. Data from the 2 years before diagnosis (or date of interview for controls) were excluded. A self-reported history of infectious mononucleosis was associated with an excess risk of NHL (OR = 1.26, 95% CI = 1.011.57 based on data from 16 studies); study-specific results indicate significant (I2 = 51%, p = 0.01) heterogeneity. A self-reported history of measles or whooping cough was associated with an approximate 15% reduction in risk. History of other infection was not associated with NHL. We find little clear evidence of an association between NHL risk and infection although the limitations of data based on self-reported medical history (particularly of childhood illness reported by older people) are well recognized.