Visfatin and its role in obesity development

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ŠŤASTNÝ Jiří BIENERTOVÁ VAŠKŮ Julie VAŠKŮ Anna

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.dsx.2012.08.011
Obor Endokrinologie, diabetologie, metabolismus, výživa
Klíčová slova Visfatin; NAMPT; Adipocytokines; Lipid metabolism; Obesity
Popis Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.

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