Informace o projektu
Exploring the protective role of cerium oxide nanoparticles against implant-induced oxidative stress in endothelial cells (FeCer)

The project will explore the use of cerium(IV) oxide nanoparticles having different morphology (nanocubes and nanowires) to rescue endothelial cells from oxidative damage caused by the release of iron ions coming from implant surfaces. By synthesizing these nanoparticles through hydrothermal methods, we aim to investigate their physicochemical properties and establish a correlation between morphology and antioxidant potential. The project focuses on assessing the cytotoxicity of iron ions and the therapeutic potential of cerium(IV) oxide nanoparticles in cellular settings. Key methodologies will include in vitro studies on endothelial cells to measure cellular viability and ROS levels, employing advanced imaging techniques and biochemical assays. Collaborations with leading research institutions, also from Poland and Denmark, will enhance the project's interdisciplinary nature, providing expertise in quantum sensing and materials characterization. Ultimately, this research aims to test an innovative solution for reducing implant-related complications, improving material biocompatibility along with patient outcomes in biomedical applications.