Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 251
2018
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Cyclopropylamine plasma polymer surfaces for label-free SPR and QCM immunosensing of Salmonella
Sensors and Actuators B: Chemical, rok: 2018, ročník: 276, vydání: DEC, DOI
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Description and comparative genomics of Macrococcus caseolyticus subsp. hominis subsp. nov., Macrococcus goetzii sp. nov., Macrococcus epidermidis sp. nov., and Macrococcus bohemicus sp. nov., novel macrococci from human clinical material with virulence potential and suspected uptake of foreign DNA by natural transformation
Frontiers in Microbiology, rok: 2018, ročník: 9, vydání: 1178, DOI
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Dny elektronové mikroskopie (prohlídka CF Cryo-EM)
Rok: 2018, druh: Popularizační texty
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Dynamics of the Pollen Sequestrome Defined by Subcellular Coupled Omics
Plant Physiology, rok: 2018, ročník: 178, vydání: 1, DOI
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Enantioselective Conjugate Additions of 2-Alkoxycarbonyl-3(2H)-furanones
Organic Letters, rok: 2018, ročník: 20, vydání: 22, DOI
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Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells
Angewandte Chemie International Edition, rok: 2018, ročník: 57, vydání: 8, DOI
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Extension of the 'Inorganic Gel Casting' Process to the Manufacturing of Boro-Alumino-Silicate Glass Foams
Materials, rok: 2018, ročník: 11, vydání: 12, DOI
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Filter-Aided Sample Preparation Procedure for Mass Spectrometric Analysis of Plant Histones
Frontiers in Plant Science, rok: 2018, ročník: 9, vydání: SEP, DOI
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Free energy calculations on the stability of the 14-3-3 zeta protein
Biochimica et Biophysica Acta - Proteins and Proteomics, rok: 2018, ročník: 1866, vydání: 3, DOI
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Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics
Journal of Biological Chemistry, rok: 2018, ročník: 293, vydání: 34, DOI