Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 252
2017
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Phosphorylation of the regulatory domain of human tyrosine hydroxylase 1 monitored using non-uniformly sampled NMR
Biophysical Chemistry, rok: 2017, ročník: 223, vydání: April, DOI
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Practical course in proteomics for FS MU students
Rok: 2017, druh: Uspořádání workshopu
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Practical course in proteomics for FS MU students II
Rok: 2017, druh: Uspořádání workshopu
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Preparation and characterization of tin nanoparticles
Rok: 2017, druh: Konferenční abstrakty
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Prohlídka laboratoří kryo-elektronové mikroskopie
Rok: 2017, druh: Popularizační texty
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Proteins binding to immobilized rusticyanin detected by affinity chromatography
Solid State Phenomena, rok: 2017
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Quantitative mapping of microtubule-associated protein 2c (MAP2c) phosphorylation and regulatory protein 14-3-3 zeta-binding sites reveals key differences between MAP2c and its homolog Tau
Journal of Biological Chemistry, rok: 2017, ročník: 292, vydání: 16, DOI
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Rapid single-step upconversion-linked immunosorbent assay for diclofenac
Microchimica Acta, rok: 2017, ročník: 184, vydání: 10, DOI
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Reversal of Stereoselectivity in Cycloadditions of Five-Membered Cyclic Nitrones Derived from Hexoses
European Journal of Organic Chemistry, rok: 2017, ročník: 2018, vydání: 6, DOI
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Science Career Fair
Rok: 2017, druh: Popularizační texty