Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 252
2017
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Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions
Nucleic Acids Research, rok: 2017, ročník: 45, vydání: 5, DOI
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Cryo-EM study of slow bee paralysis virus at low pH reveals iflavirus genome release mechanism
Proceedings of the National Academy of Sciences of the United States of America, rok: 2017, ročník: 114, vydání: 3, DOI
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Cubane Arrives on the Cucurbituril Scene
Organic Letters, rok: 2017, ročník: 19, vydání: 10, DOI
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Deep coverage of the beer proteome
Journal of Proteomics, rok: 2017, ročník: 162, vydání: JUN, DOI
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Den národních výzkumných infrastruktur
Rok: 2017, druh: Popularizační texty
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Diastereoselective Flexible Synthesis of Carbocyclic C Nucleosides
The Journal of Organic Chemistry, rok: 2017, ročník: 82, vydání: 7, DOI
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Enantioselective Synthesis of Cephalimysins B and C
Organic Letters, rok: 2017, ročník: 19, vydání: 4, DOI
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Evaluation of sample preparation protocols for spider venom profiling by MALDI-TOF MS
Toxicon, rok: 2017, ročník: 133, vydání: July, DOI
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Extensive analysis of N-H center dot center dot center dot O hydrogen bonding in four classes of phosphorus compounds: a combined experimental and database study
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, rok: 2017, ročník: 73, vydání: March, DOI
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Formation of Staphylococcus aureus biofilm in the presence of sub-lethal concentrations of disinfectants: a transcriptomic analysis using RNA-seq
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, rok: 2017, ročník: 83, vydání: 24, DOI