Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 251
2018
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RS20L protein from bacterium Ralstonia solanacearum : Studies of lectin activity and oligomerization
Rok: 2018, druh: Konferenční abstrakty
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Selectivity of original C-hexopyranosyl calix[4]arene conjugates towards lectins of different origin
Carbohydrate Research, rok: 2018, ročník: 469, vydání: NOV, DOI
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SEMIQUANTITATIVE ASSESSMENT OF DISHEVELLED-3 PHOSPHORYLATION STATUS BY MASS SPECTROMETRY
HUNGARIAN JOURNAL OF INDUSTRY AND CHEMISTRY, rok: 2018, ročník: 46, vydání: 1, DOI
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Sequencing of Treponema pallidum subsp pallidum from isolate UZ1974 using Anti-Treponemal Antibodies Enrichment: First complete whole genome sequence obtained directly from human clinical material
Plos one, rok: 2018, ročník: 13, vydání: 8, DOI
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Short-term assessment of cadmium toxicity and uptake from different types of Cd-based Quantum Dots in the model plant Allium cepa L.
Ecotoxicology and Environmental Safety, rok: 2018, ročník: 153, vydání: MAY, DOI
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Stable, nanometer-thick oxygen-containing plasma polymer films suited for enhanced biosensing
Plasma Processes and Polymers, rok: 2018, ročník: 15, vydání: 11, DOI
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Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR
Proceedings of the National Academy of Sciences of the United States of America, rok: 2018, ročník: 115, vydání: 36, DOI
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Structure and properties of AB21, a novel Agaricus bisporus protein with structural relation to bacterial pore-forming toxins
Proteins : structure, function, and genetics, rok: 2018, ročník: 86, vydání: 9, DOI
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Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
Nature Communications, rok: 2018, ročník: 9, vydání: JAN, DOI
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Student training (FEEC BUT)
Rok: 2018, druh: Popularizační texty