snímek PPT
23 Mechanisms of vascular injury
231 Systemic vasculitis and antineutrophil cytoplasmatic antibodies
Acute systemic process of arteries.
- Large vessel arteritides, e.g. polyarteritis nodosa ? distal
glomerular ischemia (no inflammation) ? ?GFR
- Glomerular tuft, e.g. polyarteritis nodosa, Wegener´s
granulomatosis ? focal glomerular necrosis, crescents,
Novel circulating autoantibody – antineutrophil cytoplasmic
Highly specific for systemic necrotizing vasculitides
ANCA ? respiratory burst of phagocytic cells ? release of free radicals ? degranulation ? injury to endothelial cells