snímek PPT
232 Thrombotic microangiopathies
Injured endothelial cell loses its natural thromboresistance ? platelet activation ? thrombi in the lumen ? possibly fibrinoid necrosis and fibrin deposition into media
Hemolytic-uremic syndrome: thrombocytopenia, microangiopathic hemolytic anemia, ?renal function
- verotoxin-producing Escherichia coli ? damage to
endothelia (infantile diarrhea); also immunosuppresives and
- ?Willebrand factor ? ?platelet aggregation; autoantibody
against inhibitors of platelet aggregation
- antibody-mediated endothelial injury in hyperacute renal