snímek PPT
Severe damage of capillary wall ? leaks (rents) in GBM ? fibrinogen and other plasma components enter Bowman´s space
Crescents = accumulation and proliferation of extracapillary cells
? compression of the glomerular tuft ? rapid renal failure
Crescentic glomerulonephritis (?50% glom.) ? rapidly progressive GN
Etiology:
- any severe GN
- anti-GBM antibody disease
- ANCA-positive disorders
Hypersensitivity reaction type II or IV (?)
Congenital defect of collagen