snímek PPT
Type II: Antibody-dependent cellular cytotoxicity (ADCC)
Cell-mediated cytotoxicity that requires prior binding of antibodies to
K(iller) cells: Lymphocyte-like cells (not B or T) that kill a variety of tumor cells and virus-infected cells but only after previous immunization
Errant or uncontrolled plasma cells produce antibodies against selfantigens
Drugs combine with body antigens (e.g., on erythrocytes)
anchor and activate K-cells ? ADCC
AB attach to the
surface of cells, bind (via Fc receptors) and activate
GBM etc. neutrophils and macrophages
activate complement cascade
damage of the cells, GBM etc.