snímek PPT
Type I: Immediate hypersensitivity (anaphylaxis)
1st exposure to antigen ? production of specific AB ? their binding
to mast cells (sensitization). Next exposure ? allergen
degranulates mast cells ? release of histamine (immediate
response) ? ?vascular permeability, ?airways, hives,
conjunctivitis, rhinitis. Later: ? leukotriens, prostaglandins, PAF,
proteases (late phase) ? localized anaphylaxis = atopy (asthma,
hay fever, eczema, hives)
systemic anaphylaxis – circulatory shock,