snímek PPT
b) Mutated RBC ? slowering of the
Na/K-ATPase ? Na into RBC ? water
into RBC ? getting spherical etc.
c) Mutated RBC ? enhanced need of
glucose ? lowered glucose
concentration in the spleen ? enhanced
trapping of the microspherocytes
Symptomatology:
Mild anemia only
Bilirubin gale stones
Osmotic fragility test - series of salt
solutions of increasing concentration
? sensitivity of RBC to a medium
without glucose