snímek PPT
32 Intravascular hemolysis or premature phagocyto-
Defects in the erythrocyte membrane
Hereditary spherocytosis
RBC flexibility is conditioned by the
unique structure of the RBC membrane,
and this is maintained by actin, spectrin,
and ankyrin. Spectrin gene mutates most
often
a) Mutated RBC ? loss of flexibility ?
pitting in the splenic sinuses ? RBC
shrinking ? getting spherical ? loss of
flexibility ? destruction in the spleen