MASARYK NEUROSCIENCE HUB

Reseach and Educational Neuroscience Platform

About Masaryk Neuroscience Hub

9 Jan 2025

THE MICROGLIAL NICHE IN NEURODEGENERATION - UNDERSTANDING PATHOLOGY AND TARGETING FOR IMMUNOTHERAPY

4:00 PM

Prof. Robert A. Harris, Sweden

20–24 Jan 2025

14TH EPODES BASIC

3:00 PM – 1:00 PM

See all events

EBRAINS welcomes Masaryk University as new associate member

28 Aug 2020

New MASARYK NEUROSCIENCE HUB website has been released.

We are happy to announce that our new website has been released.

28 Aug 2020

A unique research cluster for the treatment of stroke has been established in Brno

STROKE BRNO is an interdisciplinary research cluster with the aim of connecting the knowledge and expertise of academic and industrial partners and ensuring the effective use of knowledge from basic research in clinical practice.

Our Latest Research

6 Oct 2020

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Purpose: The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum.

15 Sep 2020

Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe.

15 Sep 2020

Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T

Functional MRI (fMRI) has become an important tool for probing network-level effects of deep brain stimulation (DBS). Previous DBS-fMRI studies have shown that electrical stimulation of the ventrolateral (VL) thalamus can modulate sensorimotor cortices in a frequency and amplitude dependent manner. Here, we investigated, using a swine animal model, how the direction and orientation of the electric field, induced by VL-thalamus DBS, affects activity in the sensorimotor cortex.

15 Sep 2020

Simple compensation method for improved half-pulse excitation profile with rephasing gradient

The overall first-order and zero-order phase errors along the slice-selection direction were obtained with the help of an optimization task to minimize the out-of-slice signal contamination from the calibration 1-dimenisonal (1D) profile data. The time-phase-error evolution was approximated from the k-space readout data, which were acquired primarily for correction of the readout trajectories during data regridding to the rectilinear grids. The correction of the slice profile was achieved by rephasing gradient pulses applied immediately after the end of excitation. The total prescan calibration typically took less than 2 minutes.

15 Sep 2020

Structural Alterations in Deep Brain Structures in Type 1 Diabetes

Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this disease, we sought to determine the possible neural correlate in long-duration T1D at several levels including macrostructural, microstructural cerebral damage and blood flow alterations.

15 Sep 2020

Detection of ischemic changes on baseline multimodal computed tomography: expert reading vs. Brainomix and RAPID software

The aim of the study was to compare the assessment of ischemic changes by expert reading and available automated software for non-contrast CT (NCCT) and CT perfusion on baseline multimodal imaging and demonstrate the accuracy for the final infarct prediction.

14 Sep 2020

miR‐183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids

MicroRNAs (miRNAs), a class of small, non-coding RNA molecules represent important regulators of gene expression. Recent reports have implicated their role in the cell specification process acting as "fine-tuners" to ensure the precise gene expression at the specific stage of cell differentiation. Here we used retinal organoids differentiated from human pluripotent stem cells (hPSCs) as a model to closely investigate the role of a sensory organ-specific and evolutionary conserved miR-183/96/182 cluster.

14 Sep 2020

Intracranial and systemic atherosclerosis in the NAVIGATE ESUS trial: Recurrent stroke risk and response to antithrombotic therapy

Non-stenotic intracranial and systemic atherosclerosis are associated with ischemic stroke. We report frequency and response to anticoagulant vs. antiplatelet prophylaxis of patients with embolic stroke of undetermined source (ESUS) who have non-stenotic intracranial atherosclerosis and/or systemic atherosclerosis.

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