The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Autoři	SAMEC Marek LISKOVA Alena KUBATKA Peter URAMOVA Sona ZUBOR Pavol SAMUEL Samson Mathews ZULLI Anthony PEC Martin BIELIK Tibor BIRINGER Kamil KUDELA Erik BENACKA Jozef ADAMEK Mariusz RODRIGO Luis CICCOCIOPPO Rachele KWON Taeg Kyu BARANENKO Denis KRUŽLIAK Peter BUSSELBERG Daniel
Rok publikování	2019
Druh	Článek v odborném periodiku
Časopis / Zdroj	Journal of cancer research and clinical oncology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	http://dx.doi.org/10.1007/s00432-019-02940-0
Doi	http://dx.doi.org/10.1007/s00432-019-02940-0
Klíčová slova	microRNAs; Phytochemicals; Plant-derived food; Cancer; Carcinogenesis
Popis	PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.