snímek PPT
223 Antibodies directed against GBM antigens
Antigen: noncollagenous portion of the ?3 chain of type IV collagen
Complement and mediators ? focal glomerular necrosis, crescent formation ? end-stage renal failure
Anti-GBM antibodies bind in a linear pattern to the GBM (without electronoptically dense deposits)
Hypersensitivity reaction type II