snímek PPT
Typically caused by passive entrapment of preformed circulating immune complexes.
The nature of the antigen ? whether subepithelial or subendothelial deposition
Postinfectious GN: Streptococci, bacterial endocarditis, hepatitis B, malaria
- Complexes in contact with circulation generate C3a and C5a
- Activation of Hageman factor ? ?coagulation cascade
- Damaged endothelium ? cytokines and autocoids (local hormones) ? ?adhesion molecules ? activation of endothelial and inflammatory cells