snímek PPT

Focal segmental glomerulosclerosis (FGS)

Focal = ?50% of glomeruli are affected by light microscopy

Diffuse = ?50% affected

Segmental = only a part of the glomerular tuft is involved

Glomerulosclerosis = obliteration of capillary lumens

Nephrotic syndrome. Edematous podocytes, fusion (“loss”) of

their foot processes.

Unclear podocyte damaging toxin – some lymphokine? React on

glucocorticoids