snímek PPT
Renin is formed mainly in the juxtaglomerular apparatus, under the influence of
- the baroreceptors in afferent arterioles (they
react on a lowered perfusion pressure, see
Goldblatt´s clamp, renovascular hypertension)
- macula densa reacting on the electrolyte
composition in the distal tubulus
- vegetative nerves: sympaticus enhances,
parasympaticus loweres the production of
The further role of RAS is both paracrine and endocrine, however