snímek PPT
RBC coating with an antibody = opsonization ? binding of MF on RBC ? pitting by means of nipping of ? RBC sphericity ? loss of flexibility ? trapping
Opsonization rarely leads to intravascular hemolysis
Symptoms of warm-type AIHA:
Are mild, hemolysis is compensated
Pitting ? spherocytes, microcytes
Direct Coombs test (Fig. 32): Antiserum against anti-RBC antibodies is formed in rabbits ? RBC agglutination. IgG alone cannot bridge the repulsive force between RBC (= zeta potential), IgG + anti-IgG antibody can do it ? agglutination
Therapy: corticosteroids, immunosuppresive drugs