snímek PPT
The drug is a hapten and in a complex with a carrier protein ? production of antibodies. Three possibilities:
- a drug with a surface RBC antigen ? neoantigen ? production of antibodies and opsonization, e.g., penicillin
- a drug and serum protein (instead of RBC protein) ? neoantigen ? complexes are deposited on RBC membrane, e.g., antimalarics, sulfonamides, phenacetin
Alfa-methyldopa (antihypertensive drug) triggers the gene for the Rh factor
With other diseases: leukemias, SLE, inf. mononukleosis