snímek PPT
At the first parturition, the RBC penetrate from the foetus into the mother ? production of anti-Rh+-antibodies. The RBC having penetrated during the parturition could be killed by timely administration of anti Rh+ antibody (RhoGAM).
In the next gravidity, small numbers of the fetal RBC may get into the maternal circulation ? anamnestic response ? higher antibody titers of IgG (readily pass the placenta) ? HDN in the foetus
Hemolysis ? erythroblastosis
Inability to conjugate bilirubin ? jaundice (possibly s.c. kernikterus, into the basal ganglia)