snímek PPT
Sickle-cell anemia, HbC disease, HbD
322 Acquired accelerated hemolysis
Approximately:
hereditary hemolysis ? factors intrinsic to the RBC
acquiered hemolysis ? factors extrinsic to the RBC
Physiological aging of RBC ? their defense mechanisms? ? intravascular hemolysis or phagocytosis in mononuclear phagocytes (MF, reticular and endothelial cells). The environmental stressing factors shorten the RBC life span further. They are present to a degree already under physiologic conditions in most people.