snímek PPT
212 Bone marrow damage or defect
Replacement of marrow by tumor (crowding out)
- myelophthisic anemia
Replacement of normal marrow by cancerous
cell line - anemia associated with
myeloproliferative disease
Local competition for nutrients, secretion of
inhibitory substances
Damage to bone marrow by physical or chemical
agents, or infections – aplastic anemia s.s.
Benzene, chloramphenicol, analgesics,
anticonvulsants, antianxiety drugs
Inherited bone marrow defect - Fanconi's
anemia: multiple congenital abnormalities,
recessive gene