Conceptual Model Enhancing Accessibility of Data from Cancer–Related Environmental Risk Assessment Studies

Authors

DUŠEK Ladislav HŘEBÍČEK Jiří KUBÁSEK Miroslav JARKOVSKÝ Jiří KALINA Jiří BAROŠ Roman BEDNÁŘOVÁ Zdenka KLÁNOVÁ Jana HOLOUBEK Ivan

Year of publication 2011
Type Article in Proceedings
Conference 9th IFIP WG 5.11 International Symposium on Environmental Software Systems: Frameworks of eEnvironment, ISESS 2011
MU Faculty or unit

Faculty of Medicine

Citation
Field Informatics
Keywords cancer risk; data discovery; data model; Persistent organic pollutants
Description This paper proposes conceptual model which can be used to facilitate the discovery, integration and analysis of environmental data in cancer-related risk studies. Persistent organic pollutants were chosen as a model because of their persistence, bioaccumulation potential and genotoxicity. Part dealing with cancer risk is primarily focused on population-based observations encompassing a wide range of epidemiologic studies, from local investigations to national cancer registries. The proposed model adopted multilayer hierarchy working with characteristics of given entities (POPs, cancer diseases as nomenclature classes) and couples "observation - measurement" as content defining classes. The proposal extends formally used taxonomy applying multidimensional set of descriptors including scores of measurement validity and precision. This solution has the potential to aid multidisciplinary data discovery and knowledge mining.

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